Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain.

ABSTRACT: It has been reported that neutrophil extracellular traps (NETs) play important roles in non-infectious diseases. In ischemic stroke, neutrophils infiltrate damaged brain tissue soon after injury and aggravate inflammation. Using a rat permanent MCAO model, we showed citrullinated histone H3⁺ (CitH3, a marker of NETosis) induction in neutrophils in leptomeninges and in peripheral blood soon after MCAO. Entry of CitH3⁺ cells occurred through leptomeninges after 6 h of MCAO and these cells were observed in cerebral cortex from 12 h and subsequently in striatum. It is interesting to note that CitH3⁺ induction began in circulating neutrophils before they migrated to brain parenchyma and they were detected as intact or lysed form. High mobility group box 1 (HMGB1

SUBMITTER: Kim SW 

PROVIDER: S-EPMC6556959 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature