Metatranscriptome of human faecal microbial communities in a cohort of adult men.

ABSTRACT: The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms' ecological configurations or transcription. We report a large-scale investigation of 372 human faecal metatranscriptomes and 929 metagenomes from a subset of 308 men in the Health Professionals Follow-Up Study. We identified a metatranscriptomic 'core' universally transcribed over time and across participants, often by different microorganisms. In contrast to the housekeeping functions enriched in this core, a 'variable' metatranscriptome included specialized pathways that were differentially expressed both across participants and among microorganisms. Finally, longitudinal metagenomic profiles allowed ecological interaction network reconstruc

SUBMITTER: Abu-Ali GS 

PROVIDER: S-EPMC6557121 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature