Adherence trajectories of buprenorphine therapy among pregnant women in a large state Medicaid program in the United States.

ABSTRACT:

Purpose

Little is known about the longitudinal patterns of buprenorphine adherence among pregnant women with opioid use disorder, especially when late initiation, nonadherence, or early discontinuation of buprenorphine during pregnancy may increase the risk of adverse outcomes. We aimed to identify distinct trajectories of buprenorphine use during pregnancy, and factors associated with these trajectories in Medicaid-enrolled pregnant women.

Methods

A retrospective cohort study included 2361 Pennsylvania Medicaid enrollees aged 15 to 46 having buprenorphine therapy during pregnancy and a live birth between 2008 and 2015. We used group-based trajectory models to identify buprenorphine use patterns in the 40 weeks prior to delivery and 12 weeks postdelivery. Multivariable multi

SUBMITTER: Lo-Ciganic WH 

PROVIDER: S-EPMC6557135 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature