Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.

ABSTRACT: We previously reported the establishment of a rare xenograft derived from a recurrent oligodendroglioma with 1p/19q codeletion. Here, we analyzed in detail the exome sequencing datasets from the recurrent oligodendroglioma (WHO grade III, recurrent O²⁰¹⁰) and the first-generation xenograft (xenograft¹). Somatic SNVs and small InDels (n = 80) with potential effects at the protein level in recurrent O²⁰¹⁰ included variants in IDH1 (NM_005896:c.395G>A; p. Arg132His), FUBP1 (NM_003902:c.1307_1310delTAGA; p.Ile436fs), and CIC (NM_015125:c.4421T>G; p.Val1474Gly). All but 2 of these 80 variants were also present in xenograft¹, along with 7 new variants. Deep sequencing of the 87 SNVs and InDels in the original tumor (WHO grad

SUBMITTER: Exner ND 

PROVIDER: S-EPMC6557204 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature