Trajectories of Symptom Change in the Treatment for Adolescents With Depression Study.

ABSTRACT:

Objective

Depression is the most prominent mental health disorder among youth and has a profound impact with respect to morbidity and mortality if not addressed. The Treatment for Adolescent Depression Study (TADS) is one of the largest randomized controlled trials that compared the effectiveness of four treatments: cognitive-behavioral therapy (CBT); fluoxetine (FLX); combined cognitive-behavioral and fluoxetine treatment (COMB); and placebo (PBO). However, meaningful heterogeneous treatment courses are masked by these group mean comparisons of treatment impact. The present study sought to characterize the acute phase symptom trajectories of the depressed teens enrolled in TADS and to explore predictors of these trajectories, including TADS treatment condition.

Method

The T

SUBMITTER: Scott K 

PROVIDER: S-EPMC6557284 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature