Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

ABSTRACT: Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription^1-3. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in organisms that produce serotonin (also known as 5-hydroxytryptamine (5-HT)). We demonstrate that tissue transglutaminase 2 can serotonylate histone H3 tri-methylated lysine 4 (H3K4me3)-marked nucleosomes, resulting in the presence of combinatorial H3K4me3Q5ser in vivo. H3K4me3Q5ser displays a ubiquitous pattern of tissue expression in mammals, with enrichment observed in brain and gut, two organ systems responsible for the bulk of 5-HT production. Genome-wide analyses of human serotonergic neurons, developing

SUBMITTER: Farrelly LA 

PROVIDER: S-EPMC6557285 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature