Genome Plasticity in Papillomaviruses and De Novo Emergence of E5 Oncogenes.

ABSTRACT: The clinical presentations of papillomavirus (PV) infections come in many different flavors. While most PVs are part of a healthy skin microbiota and are not associated to physical lesions, other PVs cause benign lesions, and only a handful of PVs are associated to malignant transformations linked to the specific activities of the E5, E6, and E7 oncogenes. The functions and origin of E5 remain to be elucidated. These E5 open reading frames (ORFs) are present in the genomes of a few polyphyletic PV lineages, located between the early and the late viral gene cassettes. We have computationally assessed whether these E5 ORFs have a common origin and whether they display the properties of a genuine gene. Our results suggest that during the evolution of Papillomaviridae, at least four events lea

SUBMITTER: Willemsen A 

PROVIDER: S-EPMC6557308 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature