Increased angiogenesis by the rotational muscle flap is crucial for nerve regeneration.

ABSTRACT:

Background

The gold standard surgical treatment of nerve injury includes direct repair, nerve graft, and neurolysis. The underlying effects (either beneficial or detrimental) of angiogenesis during nerve regeneration by rotational muscle flap have not yet determined. We assess the neurological outcome and angiogenesis of nerve injury following a rotational muscle flap.

Methods

We retrospectively analyzed the outcome of the patients with severe radial nerve injury by neurolysis and rotational muscle flap; we also mimicked the clinical situation by nerve crush followed by rotational muscle flap in animals to assess associated angiogenesis factor expression.

Results

Twenty-three out of 25 (92%) cases of severe radial nerve injury underwent neurolysis assisted by muscle f

SUBMITTER: Pan HC 

PROVIDER: S-EPMC6557495 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature