Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study.

ABSTRACT: Individual differences in cognitive function are due to a combination of heritable and non-heritable factors. A large body of evidence from clinical, cognitive, and pharmacological neuroscience implicates dopaminergic gene variants as modulators of cognitive functions. Neuroepigenetic studies demonstrate environmental factors also influence complex phenotypes by affecting gene expression regulation. To evaluate the mechanism of environmental influence on cognitive abilities, we examined if epigenetic regulation of dopaminergic genes plays a role in cognition. Using a DNA methylation profiling microarray, we used a monozygotic (MZ) twin difference design to evaluate if co-twin differences in methylation of CpG sites near six dopaminergic genes predicted differences in response inhibition an

SUBMITTER: Lewis CR 

PROVIDER: S-EPMC6557595 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature