Epigenome modulated xenobiotic detoxification pathways control DMBA-induced breast cancer in agouti A^vy/a mice.

ABSTRACT: Environmental xenobiotics with genotoxic activity are carcinogenic. However, individual differences in the susceptibility to xenobiotic-induced breast cancer remain unclear. Since epigenetic modifications could control the expression of metabolic enzymes, our goal was to determine whether epigenome modulated metabolic networks determine susceptibility to xenobiotic-induced breast cancer. The effect of epigenetic background on predisposition to carcinogen 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer development and progression was assessed using the A^vy/a mouse model. In a randomized block design, 22 isogenic A^vy/a (8 yellow, 7 slightly mottled, 7 pseudoagouti) and 8 wild type non-agouti (a/a black) age matched female mice were subjected to DMBA (30 mg/k

SUBMITTER: Mazambani S 

PROVIDER: S-EPMC6557611 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature