Genetic and epigenetic sex-specific adaptations to endurance exercise.

ABSTRACT: In recent years, the interest in personalised interventions such as medicine, nutrition, and exercise is rapidly rising to maximize health outcomes and ensure the most appropriate treatments. Exercising regularly is recommended for both healthy and diseased populations to improve health. However, there are sex-specific adaptations to exercise that often are not taken into consideration. While endurance exercise training alters the human skeletal muscle epigenome and subsequent gene expression, it is still unknown whether it does so differently in men and women, potentially leading to sex-specific physiological adaptations. Elucidating sex differences in genetics, epigenetics, gene regulation and expression in response to exercise will have great health implications, as it may enable gene t

SUBMITTER: Landen S 

PROVIDER: S-EPMC6557612 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature