Safety and value of skin test to sex hormones and sex hormone sensitivity desensitization in women with premenstrual syndrome.

ABSTRACT:

Background

Hypersensitivity to one's own sex hormones is not a new concept but it is an underappreciated one. Such a phenomenon may explain a large proportion of symptoms related to the menstrual cycle (such as premenstrual syndrome, PMS), cyclic pain syndromes or unexplained infertility. In this study we propose a novel diagnostic tool of hormonal skin testing which reveals sex hormones sensitivity with high clinical correlation, and a subsequent successful desensitization technique.

Methods

A group of 35 women with confirmed diagnosis of PMS were enrolled in the study in which they underwent a hormonal skin diagnostic skin testing procedure by intradermal injections of Progesterone (P), Estradiol (E2), Estrone (E1) and Estriol (E3). Skin reaction was monitored, and accordi

SUBMITTER: Itsekson AM 

PROVIDER: S-EPMC6557725 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature