Scoring amino acid mutation to predict pandemic risk of avian influenza virus.

ABSTRACT:

Background

Avian influenza virus can directly cross species barriers and infect humans with high fatality. As antigen novelty for human host, the public health is being challenged seriously. The pandemic risk of avian influenza viruses should be analyzed and a prediction model should be constructed for virology applications.

Results

The 178 signature positions in 11 viral proteins were firstly screened as features by the scores of five amino acid factors and their random forest rankings. The Supporting Vector Machine algorithm achieved well performance. The most important amino acid factor (Factor 5) and the minimal range of signature positions (63 amino acid residues) were also explored. Moreover, human-origin avian influenza viruses with three or four genome segments from

SUBMITTER: Qiang X 

PROVIDER: S-EPMC6557742 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature