Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD.

ABSTRACT:

Background

The causes of poor respiratory function and COPD are incompletely understood, but it is clear that genes and the environment play a role. As DNA methylation is under both genetic and environmental control, we hypothesised that investigation of differential methylation associated with these phenotypes would permit mechanistic insights, and improve prediction of COPD. We investigated genome-wide differential DNA methylation patterns using the recently released 850 K Illumina EPIC array. This is the largest single population, whole-genome epigenetic study to date.

Methods

Epigenome-wide association studies (EWASs) of respiratory function and COPD were performed in peripheral blood samples from the Generation Scotland: Scottish Family Health Study (GS:SFHS) cohort (n 

SUBMITTER: Bermingham ML 

PROVIDER: S-EPMC6557748 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature