Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1.

ABSTRACT:

Background

Despite the success of antiretroviral therapy (ART), latent HIV-1 continues to persist in a long-lived population of resting memory CD4⁺ T cells within those who are infected. Finding a safe and effective means to induce latency reversal (LR) during ART to specifically expose this latent HIV-1 cellular reservoir for immune elimination has been a major barrier to a functional cure.

Methods

In this study, we test the use of antigen-presenting type 1-polarized, monocyte-derived dendritic cells (MDC1) generated from chronic HIV-1-infected individuals on ART as a means to induce HIV-1 latency reversal in autologous CD4⁺ T cells harboring replication-competent provirus. We use the same MDC1 for ex-vivo generation of autologous HIV-1 antigen-specifi

SUBMITTER: Kristoff J 

PROVIDER: S-EPMC6557749 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature