Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.

ABSTRACT:

Background

It is well-established that activation of nuclear factor-kappa B (NF-κB) signaling plays important roles in cancer development and progression. However, the underlying mechanism by which the NF-κB pathway is constitutively activated in cancer remains largely unclear. The present study aimed to investigate the effect of PICALM interacting mitotic regulator (PIMREG) on sustaining NF-κB activation in breast cancer.

Methods

The underlying mechanisms in which PIMREG-mediated NF-κB constitutive activation were determined via immunoprecipitation, EMSA and luciferase reporter assays. The expression of PIMREG was examined by quantitative PCR and western blotting analyses and immunohistochemical assay. The effect of PIMREG on aggressiveness of breast cancer cell was measure

SUBMITTER: Jiang L 

PROVIDER: S-EPMC6557765 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature