Circulating growth/differentiation factor 15 is associated with human CD56^bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

ABSTRACT:

Background

Systemic inflammation induced by sterile or infectious insults is associated with an enhanced susceptibility to life-threatening opportunistic, mostly bacterial, infections due to unknown pathogenesis. Natural killer (NK) cells contribute to the defence against bacterial infections through the release of Interferon (IFN) γ in response to Interleukin (IL) 12. Considering the relevance of NK cells in the immune defence we investigated whether the function of NK cells is disturbed in patients suffering from serious systemic inflammation.

Methods

NK cells from severely injured patients were analysed from the first day after the initial inflammatory insult until the day of discharge in terms of IL-12 receptor signalling and IFN-γ synthesis.

Findings

During syste

SUBMITTER: Kleinertz H 

PROVIDER: S-EPMC6557805 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature