Nanofiber-expanded human CD34⁺ cells heal cutaneous wounds in streptozotocin-induced diabetic mice.

ABSTRACT: Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34⁺ cells (henceforth CD34⁺ cells) effective therapy, tested in cutaneous wounds developed in streptozotocin-induced diabetic NOD/SCID mice. We show that systemic administration of CD34⁺ cells homed to the wound site and significantly accelerated wound closure. Wound closure was associated with improved re-epithelialization and increased neovascularization; and with decreased sustained pro-inflammatory activity of NF-κB and its downstream effector molecules TNF-α, IL-1β, and IL-6 at the wound bed. This finding was further

SUBMITTER: Kanji S 

PROVIDER: S-EPMC6557810 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature