Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.

ABSTRACT: Benefits of distributed learning strategies have been extensively described in the human literature, but minimally investigated in intellectual disability syndromes. We tested the hypothesis that training trials spaced apart in time could improve learning in two distinct genetic mouse models of neurodevelopmental disorders characterized by intellectual impairments. As compared to training with massed trials, spaced training significantly improved learning in both the Ts65Dn trisomy mouse model of Down syndrome and the maternally inherited Ube3a mutant mouse model of Angelman syndrome. Spacing the training trials at 1 h intervals accelerated acquisition of three cognitive tasks by Ts65Dn mice: (1) object location memory, (2) novel object recognition, (3) water maze spatial learning. Further

SUBMITTER: Lauterborn JC 

PROVIDER: S-EPMC6557858 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature