Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement.

ABSTRACT: The herb Centella asiatica has long been considered a memory tonic. A recent review found no strong evidence for improvement of cognitive function, suggesting negative results were due to limitations in dose, standardization and product variation. We used a standardized extract of C. asiatica (ECa 233) to study behavioral, cellular and molecular effects on learning and memory enhancement. ECa 233 (10, 30, and 100 mg/kg) was given orally to normal rats twice a day for 30 days. We used the Morris water maze to test spatial learning and performed acute brain slice recording to measure changes of synaptic plasticity in the hippocampus, a core brain region for memory formation. Plasticity-related protein expressions (NR2A, NR2B, PSD-95, BDNF and TrkB) in hippocampus was also measured. Rats rece

SUBMITTER: Boondam Y 

PROVIDER: S-EPMC6557898 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature