Myeloid Derived Suppressor Cells: Key Drivers of Immunosuppression in Ovarian Cancer.

ABSTRACT: The presence of tumor infiltrating lymphocytes (TILs) is associated with a longer overall survival in advanced stage epithelial ovarian cancer. Despite the prognostic impact of TILs, response to checkpoint-inhibitors and antigen-specific active immunotherapy is limited in ovarian cancer. The goal of our study was to investigate the interaction between ovarian cancer and the innate and adaptive immune system in the ID8-fLuc syngeneic ovarian cancer mouse model. For the in vivo experiments C57BL/6, B6.129S7-Rag1^tm1Mom/J, and B6.129P2(SJL)-Myd88^tm1.1Defr/J mice were inoculated with ID8-fLuc. In vivo depletion experiments were performed using clodronate liposomes (CL), anti-CD8a, anti-GR1, anti-colony stimulating factor 1 (anti-CSF1), and TMβ1 (anti-CD122).

SUBMITTER: Baert T 

PROVIDER: S-EPMC6558014 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature