The role of natural killer cells in hepatocellular carcinoma development and treatment: A narrative review.

ABSTRACT: A major obstacle for treatment of HCC is the inadequate efficacy and limitation of the available therapeutic options. Despite the recent advances in developing novel treatment options, HCC still remains one of the major causes of cancer morbidity and mortality around the world. Achieving effective treatment and eradication of HCC is a challenging task, however recent studies have shown that targeting Natural Killer cells, as major regulators of immune system, can help with the complete treatment of HCC, restoration of normal liver function and subsequently higher survival rate of HCC patients. Studies have shown that decrease in the frequency of NK cells, their dysfunction due to several factors such as dysregulation of receptors and their ligands, and imbalance of different types of inhib

SUBMITTER: Juengpanich S 

PROVIDER: S-EPMC6558093 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature