Geptop 2.0: An Updated, More Precise, and Faster Geptop Server for Identification of Prokaryotic Essential Genes.

ABSTRACT: Geptop has performed effectively in the identification of prokaryotic essential genes since its first release in 2013. It estimates gene essentiality for prokaryotes based on orthology and phylogeny. Genome-scale essentiality data of more prokaryotic species are available, and the information has been collected into public essential gene repositories such as DEG and OGEE. A faster and more accurate toolkit is needed to meet the increasing prokaryotic genome data. We updated Geptop by supplementing more validated essentiality data into reference set (from 19 to 37 species), and introducing multi-process technology to accelerate the computing speed. Compared with Geptop 1.0 and other gene essentiality prediction models, Geptop 2.0 can generate more stable predictions and finish the computati

SUBMITTER: Wen QF 

PROVIDER: S-EPMC6558110 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature