Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

ABSTRACT: The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically. RH5 is one of the leading blood-stage Plasmodium falciparum malaria vaccine antigens and Phase I/II clinical trials of vaccines containing this antigen are currently underway. Its likely mechanism of action is to elicit antibodies that can neutralize merozoites by blocking their invasion of red blood cells (RBC). However, many other antigens could also elicit neutralizing antibodies against the merozoite, and most of these have never been compared directly to RH5. The objective of this study was to compare a range of blood-stage antigens to RH5, to identify any antigens that outperform or synergize with anti-R

SUBMITTER: Illingworth JJ 

PROVIDER: S-EPMC6558156 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature