Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells.

ABSTRACT:

Background

Investigations into the function of non-promoter DNA methylation have yielded new insights into the epigenetic regulation of gene expression. However, integrated genome-wide non-promoter DNA methylation and gene expression analyses across a wide number of tumour types and corresponding normal tissues have not been performed.

Methods

To investigate the impact of non-promoter DNA methylation on cancer pathogenesis, we performed a large-scale analysis of gene expression and DNA methylation profiles, finding enrichment in the 3'UTR DNA methylation positively correlated with gene expression. Filtering for genes in which 3'UTR DNA methylation strongly correlated with gene expression yielded a list of genes enriched for functions involving T cell activation.

Findings<

SUBMITTER: McGuire MH 

PROVIDER: S-EPMC6558231 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature