Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma.

ABSTRACT: Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as promoters and enhancers. Their expression is therefore under tight epigenetic control. We previously reported in classical Hodgkin Lymphoma (cHL) that a member of the THE1B class of LTR elements acted as a promoter for the proto-oncogene and growth factor receptor gene CSF1R and that expression of this gene is required for cHL tumour survival. However, to which extent and how such elements participate in globally shaping the unique cHL gene expression programme is unknown. To address this question we mapped the genome-wide activation of THE1-LTRs in cHL cells using a targeted next generation sequencing approach (RACE-Seq). Integration of these data with global gene expression data from

SUBMITTER: Edginton-White B 

PROVIDER: S-EPMC6558280 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature