Immune microenvironments differ in immune characteristics and outcome of glioblastoma multiforme.

ABSTRACT: Understanding the interactions between tumors and the host immune system holds great promise to uncover biomarkers for targeted therapies, predict the prognosis of patients and guide clinical treatment. However, the immune signatures of glioblastoma multiforme (GBM) remain largely unstudied in terms of systematic analyses. We aimed to classify GBM samples according to immune-related genes and complement the existing immunotherapy system knowledge. In this study, we designed a strategy to identify 3 immune subtypes representing 3 different immune microenvironments (M1-M3) and associated with prognosis. The 3 subtypes were significantly different in terms of specific immune characteristics (immune cell subpopulations, immune responses, immune cells, and checkpoint gene interactions). In addi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6558448 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature