Statin uses and mortality in colorectal cancer patients: An updated systematic review and meta-analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) remains one of the most common types of cancer and a leading cause of death worldwide. Previous studies indicated that statins may have a potential protective effect on CRC.

Methods

We conducted this meta-analysis to systematically assess the overall and cancer-specific survival benefit of statin uses on CRC patients. Related references were identified through PubMed, the Cochrane Library, Web of Science, EMBASE, and SCOPUS from inception to August 2017. Adjusted hazard ratios (HRs) were adopted to calculate summary hazard ratios (HRs) with 95% confidence intervals (95% CIs), using a random-effects model.

Results

Total fourteen studies involving 130 994 patients were included in this meta-analysis. Six studies reported the associatio

SUBMITTER: Li Y 

PROVIDER: S-EPMC6558478 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature