A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.

ABSTRACT:

Background

Canine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease.

Methods

This retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program. Associations between clinical factors and metastasis at diagnosis were estimated using logistic regression models.

Results

In humans, those with trunk tumors had higher odds of metastasis at diagnosis compared to those with lower limb tumors (OR = 2.38, 95% CI: 1.51, 3.69). A

SUBMITTER: Diessner BJ 

PROVIDER: S-EPMC6558582 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature