Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology.

ABSTRACT:

Background

Compound Kushen Injection (CKI) is a Chinese patent drug that shows good efficacy in treating lung cancer (LC). However, its underlying mechanisms need to be further clarified.

Methods

In this study, we adopted a network pharmacology method to gather compounds, predict targets, construct networks, and analyze biological functions and pathways. Moreover, molecular docking simulation was employed to assess the binding potential of selected target-compound pairs.

Results

Four networks were established, including the compound-putative target network, protein-protein interaction (PPI) network of LC targets, compound-LC target network, and herb-compound-target-pathway network. Network analysis showed that 8 targets (CHRNA3, DRD2, PRKCA, CDK1, CDK2, CHRNA5, MMP1,

SUBMITTER: Meng Z 

PROVIDER: S-EPMC6558614 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature