Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.

ABSTRACT:

Background

Survival in metastasized cutaneous melanoma (CM) has been improved with the advent of inhibitors of immune checkpoints CTLA4 and PD-1. In contrast, the response rate for inhibition of these checkpoints in uveal melanoma (UM) is very low. Other checkpoints including IDO and TIGIT may be targetable.

Methods

Sections from 6 patients with UM, who had undergone primary enucleation 1978-1995 and 6 paired liver metastases were stained immunohistochemically (SOX10, Melan-A, IDO, TIGIT, and CD8). Four tumors from patients who did not develop metastasis during a mean follow-up of 19 years, and 5 samples each of normal choroidal and liver tissue were included for comparison. The number of cells/mm² expressing IDO, TIGIT and CD8 was counted with manual and digital

SUBMITTER: Stalhammar G 

PROVIDER: S-EPMC6558646 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature