Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis.

ABSTRACT:

Background

Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data.

Methods

Systematic searches of PubMed and Scopus were undertaken to identify prospective studies recruiting adults (> 13 years) with community-acquired sepsis in sSA post-2000. Random effects meta-analysis of in-hospital and 30-day mortality was undertaken and available aetiology data also summarised by random effects meta-analysis.

Results

Fifteen studies of 2800 participants were identified. Inclusion criteria were heterogeneous. The majority of patients were HIV-infected, and Mycobacterium tuberculosis was the most common cause of blood stream infection where sought. Pooled in-hospital mort

SUBMITTER: Lewis JM 

PROVIDER: S-EPMC6558702 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature