The impact of childhood pneumococcal vaccination on hospital admissions in England: a whole population observational study.

ABSTRACT:

Background

Pneumococcal infections are major causes of morbidity and mortality worldwide. We use routine hospital admissions data and time-series modelling analysis to estimate the impact of the seven and thirteen valent pneumococcal conjugate vaccines (PCV7 and PCV13) on hospital admissions due to pneumococcal disease in England.

Methods

Hospital admissions for pneumococcal meningitis, bacteraemia and pneumonia between January 1, 2003 and December 31, 2015 were identified from the national Hospital Episode Statistics database for all age groups in England. We model the impact of pneumococcal vaccination using interrupted time series analysis. Hospital admissions prior to vaccine introduction were extrapolated to predict the expected number of admissions in the absence of pn

SUBMITTER: Shiri T 

PROVIDER: S-EPMC6558731 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature