Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine.

ABSTRACT:

Background

Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use is limited by its side effects mostly arising from a relatively low boiling point (55 °C). In this study, we developed the gallstone-dissolving compound containing an aromatic moiety, named 2-methoxy-6-methylpyridine (MMP) with higher boiling point (156 °C), and compared its effectiveness and toxicities with MTBE.

Methods

The dissolubility of MTBE and MMP in vitro was determined by placing human gallstones in glass containers with either solvent and, then, measuring their dry weights. Their dissolubility in vivo was determined by comparing the weights of solvent-treated gallstones and control (dimethyl sulfoxide)-treated gallstones, after directly inje

SUBMITTER: Choi HJ 

PROVIDER: S-EPMC6558798 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature