PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.

ABSTRACT:

Background

Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.

Methods

To identify the driver genes in GBC metastasis, we performed a mRNA microarray of metastatic GBC and paired non-tumor samples, and found PLEK2 was markedly upregulated in GBC tissues. Next, the expression of PLEK2 in GBC were examined in a larger cohort of patients by qRT-PCR, western blot and IHC staining. The clinicopathologic correlation of PLEK2 was determined by statistical analyses. The biological involvement of PLEK2 in GBC metastasis and the underlying mechanisms were investigated.

Results

In this study, we found that PLEK2 had higher expression in GBC tumor tissues compared to non-cancerous

SUBMITTER: Shen H 

PROVIDER: S-EPMC6558801 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature