Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody.

ABSTRACT:

Objective

The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal tissue homeostasis. Dysregulated BMP signaling underlies human pathologies ranging from pulmonary arterial hypertension to heterotopic ossification. Thus, understanding the basic mechanisms and regulation of BMP signaling may yield translational opportunities. Unfortunately, limited tools are available to evaluate this pathway, and genetic approaches are frequently confounded by developmental requirements or ability of pathway components to compensate for one another. Specific inhibitors for type 2 receptors are poorly represented. Thus, we sought to id

SUBMITTER: Gorrell RE 

PROVIDER: S-EPMC6558810 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature