Transcriptome analysis of responses to bluetongue virus infection in Aedes albopictus cells.

ABSTRACT:

Background

Bluetongue virus (BTV) causes a disease among wild and domesticated ruminants which is not contagious, but which is transmitted by biting midges of the Culicoides species. BTV can induce an intense cytopathic effect (CPE) in mammalian cells after infection, although Culicoides- or mosquito-derived cell cultures cause non-lytic infection with BTV without CPE. However, little is known about the transcriptome changes in Aedes albopictus cells infected with BTV.

Methods

Transcriptome sequencing was used to identify the expression pattern of mRNA transcripts in A. albopictus cells infected with BTV, given the absence of the Culicoides genome sequence. Bioinformatics analyses were performed to examine the biological functions of the differentially expressed genes. Subse

SUBMITTER: Du J 

PROVIDER: S-EPMC6558886 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature