Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome.

ABSTRACT:

Backgrounds

Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a lack of data on the effects of PCP on long-term graft outcome.

Method

This retrospective observational study analyzed 1502 adult patients who underwent kidney transplantation at Seoul National University Hospital between 2000 and 2017. After a propensity score matching was performed, the graft and survival outcomes were compared between PCP-negative and PCP-positive groups.

Results

A total of 68 patients (4.5%) developed PCP after transplantation. The multivariable Cox analysis showed that positivity for cytomegalovirus and lack of initial oral ant

SUBMITTER: Kim JE 

PROVIDER: S-EPMC6558901 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature