Unweaving the role of nuclear Lamins in neural circuit integrity.

ABSTRACT: Lamins are type-V intermediate filament proteins that comprise the nuclear lamina. Although once considered static structural components that provide physical support to the inner nuclear envelope, recent studies are revealing additional functional and regulatory roles for Lamins in chromatin organization, gene regulation, DNA repair, cell division and signal transduction. In this issue of Cell Stress, Oyston et al. (2018) reports the function of Lamin in the maintenance of nervous system integrity and neural circuit function using Drosophila. A number of laminopathies in humans exhibit age-dependent neurological phenotypes, but understanding how defects in specific neural cell types or circuitries contribute to patient phenotypes is very challenging. Drosoph

SUBMITTER: Deal SL 

PROVIDER: S-EPMC6558928 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature