Dram1 regulates DNA damage-induced alternative autophagy.
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ABSTRACT:
SUBMITTER: Nagata M
PROVIDER: S-EPMC6558930 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Dram1 regulates DNA damage-induced alternative autophagy.
Nagata Meruna M Arakawa Satoko S Yamaguchi Hirofumi H Torii Satoru S Endo Hazuki H Tsujioka Masatsune M Honda Shinya S Nishida Yuya Y Konishi Akimitsu A Shimizu Shigeomi S
Cell stress 20180307 3
Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 ...[more]
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