Elucidating the role of graft compliance mismatch on intimal hyperplasia using an ex vivo organ culture model.

ABSTRACT: There is a growing clinical need to address high failure rates of small diameter (<6 mm) synthetic vascular grafts. Although there is a strong empirical correlation between low patency rates and low compliance of synthetic grafts, the mechanism by which compliance mismatch leads to intimal hyperplasia is poorly understood. To elucidate this relationship, synthetic vascular grafts were fabricated that varied compliance independent of other graft variables. A computational model was then used to estimate changes in fluid flow and wall shear stress as a function of graft compliance. The effect of compliance on arterial remodeling in an ex vivo organ culture model was then examined to identify early markers of intimal hyperplasia. The computational model prediction of low wall shear stress of

SUBMITTER: Post A 

PROVIDER: S-EPMC6558989 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature