Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications.

ABSTRACT: Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has been proposed to act as a signaling molecule that modulates several aspects of cell biology including membrane transport. PA can be generated in eukaryotic cells by several enzymes whose activity is regulated in the context of signal transduction and enzymes that can metabolize PA thus terminating its signaling activity have also been described. Further, several studies have identified PA binding proteins and changes in their activity are proposed to be mediators of the signaling activity of this lipid. Together these enzymes and proteins constitute a PA signaling toolkit that mediates the signaling functi

SUBMITTER: Thakur R 

PROVIDER: S-EPMC6559011 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature