Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD.

ABSTRACT: The use of inhaled, fixed-dose, long-acting muscarinic antagonists (LAMA) combined with long-acting, beta₂-adrenergic receptor agonists (LABA) has become a mainstay in the maintenance treatment of chronic obstructive pulmonary disease (COPD). One of the fixed-dose LAMA/LABA combinations is the dry powder inhaler (DPI) of umeclidinium bromide (UMEC) and vilanterol trifenatate (VI) (62.5 µg/25 µg) approved for once-a-day maintenance treatment of COPD. This paper reviews the use of fixed-dose combination LAMA/LABA agents focusing on the UMEC/VI DPI inhaler in the maintenance treatment of COPD. The fixed-dose combination LAMA/LABA inhaler offers a step beyond a single inhaled maintenance agent but is still a single device for the COPD patient having frequent COPD exacerbations and p

SUBMITTER: Albertson TE 

PROVIDER: S-EPMC6559138 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature