An Inflammatory Landscape for Preoperative Neurologic Deficits in Glioblastoma.

ABSTRACT: Introduction: Patients with glioblastoma (GBM), one of the most aggressive forms of primary brain tumors, exhibit a wide range of neurologic signs, ranging from headaches to neurologic deficits and cognitive impairment, at first clinical presentation. While such variability is attributed to inter-individual differences in increased intracranial pressure, tumor infiltration, and vascular compromise, a direct association with disease stage, tumor size and location, edema, and necrotic cell death has yet to be established. The lack of specificity of neurologic symptoms often confounds the diagnosis of GBM. It also limits clinicians' ability to elect treatment regimens that not only prolong survival but also promote symptom management and high quality of life. Methods: To deciphe

SUBMITTER: Katrib A 

PROVIDER: S-EPMC6559211 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature