High-resolution computational modeling of immune responses in the gut.

ABSTRACT:

Background

Helicobacter pylori causes gastric cancer in 1-2% of cases but is also beneficial for protection against allergies and gastroesophageal diseases. An estimated 85% of H. pylori-colonized individuals experience no detrimental effects. To study the mechanisms promoting host tolerance to the bacterium in the gastrointestinal mucosa and systemic regulatory effects, we investigated the dynamics of immunoregulatory mechanisms triggered by H. pylori using a high-performance computing-driven ENteric Immunity SImulator multiscale model. Immune responses were simulated by integrating an agent-based model, ordinary, and partial differential equations.

Results

The outputs were analyzed using 2 sequential stages: the first used a partial rank correlation coefficient regression-

SUBMITTER: Verma M 

PROVIDER: S-EPMC6559340 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature