GlycA, a novel inflammatory marker, is associated with subclinical coronary disease.

ABSTRACT:

Objective

GlycA, a novel NMR biomarker of inflammation, has been associated with incident cardiovascular disease (CVD) in the general population, but its association with CVD among HIV-infected individuals is unknown. We examined the associations between GlycA and subclinical coronary plaque among HIV-infected and HIV-uninfected men participating in Multicenter AIDS Cohort Study (MACS).

Design

Cross-sectional analysis of 935 men with plasma measurement of GlycA and noncontrast cardiac computed tomography (CT) and/or coronary CT angiography.

Methods

We used multivariable Poisson and linear regression to assess associations of GlycA with prevalent coronary atherosclerosis and plaque extent, respectively.

Results

Mean ± SD age was 54 ± 7 years; 31% were black; 63%

SUBMITTER: Tibuakuu M 

PROVIDER: S-EPMC6559349 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature