A Hallucinogenic Serotonin-2A Receptor Agonist Reduces Visual Response Gain and Alters Temporal Dynamics in Mouse V1.

ABSTRACT: Sensory perception arises from the integration of externally and internally driven representations of the world. Disrupted balance of these representations can lead to perceptual deficits and hallucinations. The serotonin-2A receptor (5-HT_2AR) is associated with such perceptual alterations, both in its role in schizophrenia and in the action of hallucinogenic drugs. Despite this powerful influence on perception, relatively little is known about how serotonergic hallucinogens influence sensory processing in the neocortex. Using widefield and two-photon calcium imaging and single-unit electrophysiology in awake mice, we find that administration of the hallucinogenic selective 5-HT_2AR agonist DOI (2,5-dimethoxy-4-iodoamphetamine) leads to a net reduction in visual respon

SUBMITTER: Michaiel AM 

PROVIDER: S-EPMC6559379 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature