Whole genome sequence of Vibrio cholerae directly from dried spotted filter paper.

ABSTRACT:

Background

Global estimates for cholera annually approximate 4 million cases worldwide with 95,000 deaths. Recent outbreaks, including Haiti and Yemen, are reminders that cholera is still a global health concern. Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of health facilities, especially in remote areas or areas of civil unrest. Recent studies demonstrated that stool specimens preserved on filter paper facilitate molecular analysis of Vibrio cholerae in resource limited settings. Specimens preserved in a rapid, low-cost, safe and sustainable manner for sequencing provides previously unavailable data about circulating cholera strains. This may ultimately contribute new information to shape public policy response on cholera control and eliminat

SUBMITTER: Benard AHM 

PROVIDER: S-EPMC6559667 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature