Using bidirectional chemical exchange for improved hyperpolarized [¹³ C]bicarbonate pH imaging.

ABSTRACT:

Purpose

Rapid chemical exchange can affect SNR and pH measurement accuracy for hyperpolarized pH imaging with [¹³ C]bicarbonate. The purpose of this work was to investigate chemical exchange effects on hyperpolarized imaging sequences to identify optimal sequence parameters for high SNR and pH accuracy.

Methods

Simulations were performed under varying rates of bicarbonate-CO₂ chemical exchange to analyze exchange effects on pH quantification accuracy and SNR under different sampling schemes. Four pulse sequences, including 1 new technique, a multiple-excitation 2D EPI (multi-EPI) sequence, were compared in phantoms using hyperpolarized [¹³ C]bicarbonate, varying parameters such as tip angles, repetition time, order of metabolite excitation, a

SUBMITTER: Korenchan DE 

PROVIDER: S-EPMC6559833 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature