Common genetic variants have associations with human cortical brain regions and risk of schizophrenia.

ABSTRACT: Schizophrenia is a highly heritable mental disorder and is reported to be associated with measurements in cortical regions of the human brain. In this study, we considered genome-wide association studies to uncover genetic effects on cortical regions and prodromal symptoms of schizophrenia. Specifically, area, thickness, and volume of 66 cortical regions derived from magnetic resonance imaging scans of 1,445 children and adolescents from the Philadelphia Neurodevelopmental Cohort were studied. Two common variants were identified as being associated with two prefrontal cortical regions (one significant variant rs11601331 on chromosome 11p11 for right rostral middle frontal gyral area, p = 1.97 × 10 -8 ; one suggestive variant rs2345981 on chromosome 6q11 for left frontal pole gyral volume,

SUBMITTER: Bi X 

PROVIDER: S-EPMC6559856 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature